Monodisperse Nanoliter Dispensing of Reagents Enabling Medical Diagnostic Biosensor Manufacturing
The significant advancements happening now in medical diagnostic biosensor development are especially noticeable to electrochemical sensors. These sensors require precision reagent dispensing with pump technologies that can provide exceptional volume and placement accuracy.
Traditionally, reagent dispensing in biosensor production was performed manually or with automatic pipettes. This often resulted in droplets of varying sizes, leading to inconsistencies and uncertainties in biosensor results. By contrast, precision dispensing is crucial for ensuring more reliable sensor performance. In the past, reagent dispensing in biosensor production relied on microliter volumes, which often led to material wastage, increased production costs, and limitations in device miniaturization. Nanoliter dispensing, in contrast, involves the precise delivery of reagents in lower uncertainty. This precision minimizes reagent consumption, reduces production costs, and facilitates the creation of smaller, more portable biosensors.
Reagents are the significant cost component of a biosensor. Precision formation and deposition of droplets for both contact and non-contact applications enables consistent expense management of costly reagents. Pump technologies that aspirate exact amounts further mitigate cost risks, particularly in R&D environments where droplet deposition occurs intermittently rather than at full production volume.
It is also helpful that a nanoliter dispensing solution scale from lab to production so that process controls developed in R&D transfer with minimal changes to full rate production lines.
At Ginolis, our patented unique positive pressure nanoliter dispensing pumps were designed to further biosensor miniaturization, functionality, and affordability, from laboratory to production. Our pumps dispense monodisperse droplets of various reagents quickly and precisely, with a coefficient of variation (CV) less than 1%. Combined with Ginolis’ precision automation robotics, our solutions meet the microfluidic requirements essential for biosensor development and manufacturing.
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