Insights article Precision in Sample Handling: The Key to Reliable Experiments

14.4.2025Ali KalantarifardMicrofluidics Specialist

Ensuring accurate and precise liquid handling is crucial for reproducibility and reliability in experiments. Without it, the entire process can falter, leading to inconsistent and unreliable results.

Today’s blog is 480 words long, and a 10 minute read.

Overview

Precision in liquid handling is essential for achieving consistent and reliable experimental outcomes. Advanced pipetting systems and automated liquid handlers are designed to handle a wide range of liquids, including those with different viscosities and densities. These systems play a vital role in maintaining the accuracy and precision required for biochemical applications.

Key Benefits

One of the primary advantages of advanced liquid handling systems is their ability to dispense very small volumes with high precision. This accuracy reduces manual errors and improves efficiency, which is particularly important in large-scale experiments. Automated systems also increase throughput, allowing researchers to save time and focus on more critical aspects of their work.

GINOLIS Low-Volume Ultra-Precision Dispensing

A significant trend in R&D labs is the need for low-volume ultra-precision dispensing. Imagine a scenario where you need to immobilize a biological material on an electrode to create an electrochemical biosensor. Handling tiny volumes of liquid with extreme precision is essential to ensure accurate and reproducible results. This is where GINOLIS low-volume ultra-precision dispensing systems come into play.

These systems help reduce the volume of samples and reagents, saving costs and materials, which is crucial when conducting numerous tests. More importantly, ultra-precision dispensers can produce monodisperse droplets with a coefficient of variation less than 1%. This level of precision is vital in fields like diagnostics and drug development, where even small deviations can lead to significant differences in outcomes.

Compared to manual pipetting or even multichannel pipetting, these dispensing machines operate at much higher speeds, dispensing hundreds of droplets per second. They are not limited to dispensing alone; they also allow for sample enrichment, dilution, and aspiration. These tasks are performed more precisely and rapidly than manual methods. Additionally, these machines are flexible and versatile, capable of dispensing at different speeds as needed. For instance, some experiments may require gradual dispensing, while others may need a sudden and fast droplet.

Moreover, these systems can enhance reactions within the reagent droplet by controlling the mixing and evaporation rate. By integrating a drying or incubation chamber, researchers can control temperature and relative humidity during the process. Low-volume ultra-precision dispensing also allows for dispensing according to a given pattern. Researchers can program the device to dispense different reagents in various volumes at specific locations.

Conclusion

In conclusion, precise sample handling is a cornerstone of reliable and reproducible experiments. Advanced GINOLIS dispensers offer significant benefits in terms of accuracy, versatility, and efficiency. By adopting these technologies, modern R&D labs can ensure precise and reproducible dispensing, minimize reagent use, and process samples quickly. This aligns perfectly with the trends and needs of future-ready assay production, paving the way for advancements in various scientific fields.